Results
| PMID | 14556808 |
| Gene Name | IL18 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 76 |
| Population details | 76 (50 untreated endometriosis, 8 women on GnRH agonists for endometriosis,8 control women with normal pelvic anatomy who were undergoing tubal ligation.) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2003 Oct;80(4):889-94. Arici, Aydin| Matalliotakis, Ioannis| Goumenou, Anastasia| Koumantakis, Georgios| Vassiliadis, Simon| Mahutte, Neal G Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA. aydin.arici@yale.edu OBJECTIVE: Peritoneal fluid (PF) inflammatory factors may participate in the pathogenesis of endometriosis. The aim of this study was to investigate PF interleukin (IL)-18 levels in women with and without endometriosis. DESIGN: Controlled clinical study. SETTING: Women undergoing laparoscopy at a university hospital. PATIENT(S): Fifty women with previously untreated endometriosis, 8 women on GnRH agonists for endometriosis, and 18 control women with normal pelvic anatomy who were undergoing tubal ligation. INTERVENTION(S): Peritoneal fluid IL-18 levels as measured by ELISA. MAIN OUTCOME MEASURE(S): Peritoneal fluid IL-18 levels. RESULT(S): Peritoneal fluid IL-18 levels were significantly higher in women with previously untreated endometriosis (mean +/- SEM, 91.1 +/- 6.5 pg/mL) than in control women (59.4 +/- 2.0 pg/mL). Interestingly, women with superficial (100.0 +/- 10.2 pg/mL) and deep peritoneal implants (94.0 +/- 10.8 pg/mL) had significantly higher PF IL-18 levels than did women with endometriomas (57.8 +/- 1.8 pg/mL). Similarly, women with stage I-II endometriosis (97.3 +/- 8.0 pg/mL), but not women with stage III-IV endometriosis (74.9 +/- 9.9 pg/mL), had significantly higher PF IL-18 levels than did control women. Peritoneal fluid IL-18 levels were significantly higher in the luteal phase than in the follicular phase but did not discriminate between women with pelvic pain or infertility. CONCLUSION(S): Peritoneal fluid IL-18 is elevated in women with peritoneal, minimal- to mild-stage endometriosis. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Endometriosis/*metabolism/pathology| Enzyme-Linked Immunosorbent Assay| Female| Follicular Phase/metabolism| Humans| Interleukin-18/*metabolism| Luteal Phase/metabolism| Severity of Illness Index|DA 2003/12/03 05 |
|